Nitro Man rides around in his bike mode and tries to ram into Mega Man, Proto Man or Bass. Afterwards, he will perform a wheelie, ride up the wall, change back into his normal mode, and fire Wheel Cutters. Nitro Man will also throw several Wheel Cutters while on the ground.
On Easy Mode, he only throws one Wheel Cutter at a time and never performs wheelies; the player should just keep jumping and they should not be hit if careful.
On Hard Mode, his bike mode is extremely fast and he runs a short path again and again instead of across the room.
Chill Spike works best against Nitro Man, since the shot will freeze him (and force him to restart his attack pattern) and the spikes both destroy Wheel Cutters and do heavy damage to him.